脂肪肝和壓力荷爾蒙

皮質醇 (cortisol)類固醇,主要壓力荷爾蒙之一。

Cortisol And Fatty Liver: Researchers Find Cause Of Severe Metabolic Disorders

ScienceDaily (Sep. 11, 2008)

http://www.sciencedaily.com/releases/2008/09/080909131223.htm

 

Dr. Stephan Herzig, head of the Junior Research Group "Molecular Metabolic Control" at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), and his team have now published the mechanism by which the body's own glucocorticoid hormones contribute to this disruption of the lipid metabolism.

The researchers in Herzig's team specifically switched off the cortisol receptor in the livers of mice, thus blocking the hormone's effect. As a result, the triglyceride level in the livers of the experimental animals dropped considerably. Investigations have revealed that, in the absence of the cortisol receptor, large amounts of the HES1 protein are produced in the livers of these animals

 

 

Associations between liver histology and cortisol secretion in subjects with nonalcoholic fatty liver disease

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2006.02466.x/full

 

  1. Giovanni Targher1,3, 
  2. Lorenzo Bertolini1,
  3. Stefano Rodella2, 
  4. Giacomo Zoppini3,
  5. Luciano Zenari1, 
  6. Giancarlo Falezza1

Article first published online: 9 FEB 2006

DOI: 10.1111/j.1365-2265.2006.02466.x

High Cortisol and Fatty Liver:

The connection between high cortisol and a fatty liver is outlined by researchers in the "Clinical Endocrinology" journal, which found that nonalcoholic fatty liver disease had signs of chronic hyperactivity within their hypothalamo-pituitary-adrenal axis, which causes an overproduction of cortisol and Cushing syndrome.

While this finding is not completely supported, and further testing is required, researchers believe that high cortisol levels can lead to fatty liver disease because cortisol promotes fat deposits within your liver.

How Cortisol Levels Are Elevated:

Now that we understand there is a potential correlation between high cortisol levels and fatty liver disease, how exactly are cortisol levels raised?

The increase in cortisol production may be caused by excessive psychological stress and excessive physical stress. They hyperactivity within your adrenal axis, as outlined above, can occur due to certain medications, such as corticosteroid, as well as excessive production of the ACTH hormone and tumors on your adrenal gland.

Fatty Liver and Cortisol Reduction:

As outlined above, there is a direct connection between high cortisol levels and fatty liver disease; however, this raises the question: Can you reduce the harm of fatty liver disease by lowering cortisol levels? The answer: Possibly Yes.

The Helmholtz Association of German Research Centers performed a research study where scientists turned off cortisol receptors in mice. By doing so, researchers noted that the decrease of cortisol levels increased the production of the HES1 protein. This specific protein works by breaking down fat deposits located in the liver. Thus, the end result is an overall reduction of fatty deposits within your liver.